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Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells
International Journal of Molecular Sciences, 22 (2021), 9; 4399. https://doi.org/10.3390/ijms22094399
Rački, Valentino; Marcelic, Marina; Štimac, Igor; Petrić, Daniela; Kučić, Natalia

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Rački, V., Marcelic, M., Štimac, I., Petrić, D. i Kučić, N. (2021). Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells. International Journal of Molecular Sciences, 22. (9). doi: 10.3390/ijms22094399

Rački, Valentino, et al. "Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells." International Journal of Molecular Sciences, vol. 22, br. 9, 2021. https://doi.org/10.3390/ijms22094399

Rački, Valentino, Marina Marcelic, Igor Štimac, Daniela Petrić i Natalia Kučić. "Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells." International Journal of Molecular Sciences 22, br. 9 (2021). https://doi.org/10.3390/ijms22094399

Rački, V., et al. (2021) 'Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells', International Journal of Molecular Sciences, 22(9). doi: 10.3390/ijms22094399

Rački V, Marcelic M, Štimac I, Petrić D, Kučić N. Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells. International Journal of Molecular Sciences [Internet]. 22.04.2021. [pristupljeno 24.12.2024.];22(9). doi: 10.3390/ijms22094399

V. Rački, M. Marcelic, I. Štimac, D. Petrić i N. Kučić, "Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells", International Journal of Molecular Sciences, vol. 22, br. 9, Travanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:035173. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:035173
Podaci o radu
Naslov (engleski)Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells
AutorValentino Rački
AutorMarina Marcelic
AutorIgor Štimac
AutorDaniela Petrić
AutorNatalia Kučić
MBZ: 239812
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za neurologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za psihijatriju i psihološku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
Microglial cells are resident macrophages in the brain that have been implicated in the pathophysiology of schizophrenia. There is a lack of studies covering the effects of antipsychotics on microglial cells. The current literature points to a possible anti-inflammatory action without clear mechanisms of action. The aim of this study is to characterize the effects of haloperidol, risperidone and aripiprazole on BV-2 microglial cells in in vitro conditions. We have used immunofluorescence and flow cytometry to analyze the classical pro and anti-inflammatory markers, while a real-time metabolic assay (Seahorse) was used to assess metabolic function. We analyzed the expression of p70S6K to evaluate the mTOR pathway activity with Western blot. In this study, we demonstrate the varying effects of haloperidol, risperidone and aripiprazole administration in BV-2 microglial cells. All three tested antipsychotics were successful in reducing the pro-inflammatory action of microglial cells, although only aripiprazole increased the expression of anti-inflammatory markers. Most significant differences in the possible mechanisms of action were seen in the real-time metabolic assays and in the mTORC1 signaling pathway activity, with aripiprazole being the only antipsychotic to reduce the mTORC1 activity. Our results shed some new light on the effects of haloperidol, risperidone and aripiprazole action in microglial cells, and reveal a novel possible mechanism of action for aripiprazole.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 22, br. 9, 4399
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22094399
URN:NBNurn:nbn:hr:184:035173
Datum objave publikacije2021-04-22
ProjektŠifra: 13.06.1.3.45,
Naziv (hrvatski): Endocitoza MHC molekula I razreda u mikroglijalnim stanicama inficiranih citomegalovirusom
Voditelj: Natalija Kučić
Pravna nadležnost: Hrvatska
Financijer: UNIRI
URL dokumentahttps://www.mdpi.com/1422-0067/22/9/4399
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-05-13 20:13:02