prikaz prve stranice dokumenta Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness
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Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness
International Journal of Molecular Sciences, 22 (2021), 16; 9095. https://doi.org/10.3390/ijms22169095
Mušković, Martina; Ćavar, Iva; Lesar, Andrija; Lončarić, Martin; Malatesti, Nela; Gobin, Ivana

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Mušković, M., Ćavar, I., Lesar, A., Lončarić, M., Malatesti, N. i Gobin, I. (2021). Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness. International Journal of Molecular Sciences, 22. (16). doi: 10.3390/ijms22169095

Mušković, Martina, et al. "Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness." International Journal of Molecular Sciences, vol. 22, br. 16, 2021. https://doi.org/10.3390/ijms22169095

Mušković, Martina, Iva Ćavar, Andrija Lesar, Martin Lončarić, Nela Malatesti i Ivana Gobin. "Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness." International Journal of Molecular Sciences 22, br. 16 (2021). https://doi.org/10.3390/ijms22169095

Mušković, M., et al. (2021) 'Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness', International Journal of Molecular Sciences, 22(16). doi: 10.3390/ijms22169095

Mušković M, Ćavar I, Lesar A, Lončarić M, Malatesti N, Gobin I. Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness. International Journal of Molecular Sciences [Internet]. 23.08.2021. [pristupljeno 28.04.2024.];22(16). doi: 10.3390/ijms22169095

M. Mušković, I. Ćavar, A. Lesar, M. Lončarić, N. Malatesti i I. Gobin, "Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness", International Journal of Molecular Sciences, vol. 22, br. 16, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:159718. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:159718
Podaci o radu
Naslov (engleski)Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness
AutorMartina Mušković
AutorIva Ćavar
AutorAndrija Lesar
AutorMartin Lončarić
AutorNela Malatesti
AutorIvana Gobin
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak (engleski)
The bacterium Legionella pneumophila is still one of the probable causes of waterborne diseases, causing serious respiratory illnesses. In the aquatic systems, L. pneumophila exists inside free-living amoebae or can form biofilms. Currently developed disinfection methods are not sufficient for complete eradication of L. pneumophila biofilms in water systems of interest. Photodynamic inactivation (PDI) is a method that results in an antimicrobial effect by using a combination of light and a photosensitizer (PS). In this work, the effect of PDI in waters of natural origin and of different hardness, as a treatment against L. pneumophila biofilm, was investigated. Three cationic tripyridylporphyrins, which were previously described as efficient agents against L. pneumophila alone, were used as PSs. We studied how differences in water hardness affect the PSs’ stability, the production of singlet oxygen, and the PDI activity on L. pneumophila adhesion and biofilm formation and in biofilm destruction. Amphiphilic porphyrin showed a stronger tendency for aggregation in hard and soft water, but its production of singlet oxygen was higher in comparison to tri- and tetracationic hydrophilic porphyrins that were stable in all water samples. All three studied porphyrins were shown to be effective as PDI agents against the adhesion of the L. pneumophila to polystyrene, against biofilm formation, and in the destruction of the formed biofilm, in their micromolar concentrations. However, a higher number of dissolved ions, i.e., water hardness, generally reduced somewhat the PDI activity of all the porphyrins at all tested biofilm growth stages.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 22, br. 16, 9095
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22169095
URN:NBNurn:nbn:hr:184:159718
Datum objave publikacije2021-08-23
URL dokumentahttps://www.mdpi.com/1422-0067/22/16/9095
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-09-03 09:22:13