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Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of
Infection and Immunity, 78 (2010), 3; 1123-1134. https://doi.org/10.1128/IAI.00913-09
Habyarimana, Fabien; Price, Chris T.; Šantić, Marina; Al-Khodor, Souhaila; Kwaik, Yousef Abu

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Habyarimana, F., Price, C. T., Šantić, M., Al Khodor, S. i Kwaik, Y. A. (2010). Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of. Infection and Immunity, 78. (3), 1123-1134. doi: 10.1128/IAI.00913-09

Habyarimana, Fabien, et al. "Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of." Infection and Immunity, vol. 78, br. 3, 2010, str. 1123-1134. https://doi.org/10.1128/IAI.00913-09

Habyarimana, Fabien, Chris T. Price, Marina Šantić, Souhaila Al Khodor i Yousef Abu Kwaik. "Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of." Infection and Immunity 78, br. 3 (2010): 1123-1134. https://doi.org/10.1128/IAI.00913-09

Habyarimana, F., et al. (2010) 'Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of', Infection and Immunity, 78(3), str. 1123-1134. doi: 10.1128/IAI.00913-09

Habyarimana F, Price CT, Šantić M, Al Khodor S, Kwaik YA. Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of. Infection and Immunity [Internet]. 03.2010. [pristupljeno 15.05.2024.];78(3):1123-1134. doi: 10.1128/IAI.00913-09

F. Habyarimana, C. T. Price, M. Šantić, S. Al Khodor i Y. A. Kwaik, "Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of", Infection and Immunity, vol. 78, br. 3, str. 1123-1134, Ožujak 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:239208. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:239208
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Naslov (engleski)Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of
AutorFabien Habyarimana
AutorChris T. Price
AutorMarina Šantić
AutorSouhaila Al-Khodor
AutorYousef Abu Kwaik
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
ABSTRACT Although most Dot/Icm-translocated effectors of are not required for intracellular proliferation, the eukaryotic-like ankyrin effectors, AnkH and AnkJ are required for intracellular proliferation. In this report, we show that the IcmSW chaperones are essential for translocation of AnkJ but not AnkH. The 10 C-terminal residues and the ANK domains of AnkH and AnkJ are required for translocation. Our data indicate that the two ANK domains of AnkH are critical domains required for the function of the effector in intracellular replication of . The and mutants are severely defective in intrapulmonary proliferation in mice. Expression of AnkH and AnkJ fusions within HEK293 cells show a punctuate distribution in the cytosol but no association with endocytic vesicles, the Golgi apparatus or the endoplasmic reticulum. Interestingly, the defect in intracellular proliferation of the or mutants is rescued in HEK293 cells expressing the respective protein. We conclude that AnkH and AnkJ are effectors translocated by the Dot/Icm system by distinct mechanisms and modulate distinct cytosolic processes in the host cell.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInfection and Immunity
Brojčani podacivol. 78, br. 3, str. 1123-1134
p-ISSN0019-9567
e-ISSN1098-5522
DOIhttps://doi.org/10.1128/IAI.00913-09
URN:NBNurn:nbn:hr:184:239208
Datum objave publikacije2010-03
URL dokumentahttps://journals.asm.org/doi/10.1128/IAI.00913-09
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-28 09:26:38