prikaz prve stranice dokumenta Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila
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Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila
Journal of Experimental Medicine, 207 (2010), 8; 1713-1726. https://doi.org/10.1084/jem.20100771
Price, Christopher T.D.; Al-Quadan, Tasneem; Šantić, Marina; Jones, Snake C.; Abu Kwaik, Yousef

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Price, C. T., Al Quadan, T., Šantić, M., Jones, S. C. i Abu Kwaik, Y. (2010). Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila. Journal of Experimental Medicine, 207. (8), 1713-1726. doi: 10.1084/jem.20100771

Price, Christopher T.D., et al. "Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila." Journal of Experimental Medicine, vol. 207, br. 8, 2010, str. 1713-1726. https://doi.org/10.1084/jem.20100771

Price, Christopher T.D., Tasneem Al Quadan, Marina Šantić, Snake C. Jones i Yousef Abu Kwaik. "Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila." Journal of Experimental Medicine 207, br. 8 (2010): 1713-1726. https://doi.org/10.1084/jem.20100771

Price, C. T., et al. (2010) 'Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila', Journal of Experimental Medicine, 207(8), str. 1713-1726. doi: 10.1084/jem.20100771

Price CT, Al Quadan T, Šantić M, Jones SC, Abu Kwaik Y. Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila. Journal of Experimental Medicine [Internet]. 02.08.2010. [pristupljeno 15.05.2024.];207(8):1713-1726. doi: 10.1084/jem.20100771

C. T. Price, T. Al Quadan, M. Šantić, S. C. Jones i Y. Abu Kwaik, "Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila", Journal of Experimental Medicine, vol. 207, br. 8, str. 1713-1726, Kolovoz 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:142635. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:142635
Podaci o radu
Naslov (engleski)Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila
AutorChristopher T.D. Price
AutorTasneem Al-Quadan
AutorMarina Šantić
AutorSnake C. Jones
AutorYousef Abu Kwaik
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Farnesylation involves covalent linkage of eukaryotic proteins to a lipid moiety to anchor them into membranes, which is essential for the biological function of Ras and other proteins. A large cadre of bacterial effectors is injected into host cells by intravacuolar pathogens through elaborate type III–VII translocation machineries, and many of these effectors are incorporated into the pathogen-containing vacuolar membrane by unknown mechanisms. The Dot/Icm type IV secretion system of Legionella pneumophila injects into host cells the F-box effector Ankyrin B (AnkB), which functions as platforms for the docking of polyubiquitinated proteins to the Legionella-containing vacuole (LCV) to enable intravacuolar proliferation in macrophages and amoeba. We show that farnesylation of AnkB is indispensable for its anchoring to the cytosolic face of the LCV membrane, for its biological function within macrophages and Dictyostelium discoideum, and for intrapulmonary proliferation in mice. Remarkably, the protein farnesyltransferase, RCE-1 (Ras-converting enzyme-1), and isoprenyl cysteine carboxyl methyltransferase host farnesylation enzymes are recruited to the LCV in a Dot/Icm-dependent manner and are essential for the biological function of AnkB. In conclusion, this study shows novel localized recruitment of the host farnesylation machinery and its anchoring of an F-box effector to the LCV membrane, and this is essential for biological function in vitro and in vivo.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 207, br. 8, str. 1713-1726
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20100771
URN:NBNurn:nbn:hr:184:142635
Datum objave publikacije2010-08-02
URL dokumentahttps://rupress.org/jem/article/207/8/1713/46048/Exploitation-of-conserved-eukaryotic-host-cell
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-28 09:44:47