prikaz prve stranice dokumenta Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection
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Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection
Na: The 45th FEBS Virtual Congress. Virtual meeting, Slovenija, 2021. urn:nbn:hr:184:007576
Pavišić, Valentino; Mahmutefendić Lučin, Hana; Lučin, Pero; Blagojević Zagorac, Gordana

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Pavišić, V., Mahmutefendić Lučin, H., Lučin, P. i Blagojević Zagorac, G. Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection [PowerPoint prezentacija]. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:007576

Pavišić, Valentino, et al. "Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection." The 45th FEBS Virtual Congress, 03.07.2021.-08.07.2021., Virtual meeting, Slovenija. Prezentacija. https://urn.nsk.hr/urn:nbn:hr:184:007576

Pavišić, Valentino, Hana Mahmutefendić Lučin, Pero Lučin i Gordana Blagojević Zagorac. "Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection." Prezentacija sa skupa The 45th FEBS Virtual Congress, Virtual meeting, Slovenija, 03.07.2021.-08.07.2021. https://urn.nsk.hr/urn:nbn:hr:184:007576

Pavišić, V., et al. 'Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection' [Prezentacija], The 45th FEBS Virtual Congress. 03.07.2021.-08.07.2021. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:007576

Pavišić V, Mahmutefendić Lučin H, Lučin P, Blagojević Zagorac G. Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection. [Prezentacija] [pristupljeno 23.11.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:007576

V. Pavišić, H. Mahmutefendić Lučin, P. Lučin i G. Blagojević Zagorac, "Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection", prezentirano na: The 45th FEBS Virtual Congress, Virtual meeting, 03.07.2021.-08.07.2021. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:007576

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:007576
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Naslov (engleski)Arf proteins accumulate in the citomegalovirus assembly compartment during the early phase of infection
AutorValentino Pavišić
AutorHana Mahmutefendić Lučin
AutorPero Lučin
AutorGordana Blagojević Zagorac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Citomegaloviruses (CMVs) are DNA viruses that can cause severe disease in immunocompromised persons. Very early during infection, CMVs extensively reorganize membranous compartments of the host cells which finally results with formation of virion assembly compartment (VAC). Since Arf GTPases are one of the major regulators of cellular membrane dynamics we hypothesized that CMVs manipulate Arf protein system in order to ensure favorable conditions for their replication. To address this hypothesis, we infected Balb 3T3 cells with murine CMV (MCMV), since organization structure of human and murine VAC is similar but at the same time murine MCMV replication cycle is much shorter and therefore more suitable for studying. In MCMV infected cells expression of class I (Arf1, Arf3), clas II (Arf4, Arf5) and clas II (Arf6) proteins was determined with Western blot and immunofluorescent microscopy in the early phase of the infection. To determine their intracellular localization, each of the Arf proteins was colocalized with markers of early and late endosomal compartments, markers of Golgi complex, as well as with different early phase viral proteins. Our results indicate that Arf proteins are overexpressed (Arf1-5) or overactivated (Arf6) during the early phase of CMV infection. They also change their intracellular localization and are accumulated in the inner part of VAC where they colocalize with markers of early and recycling endosomes. Better understanding of VAC formation and the role that Arf proteins play in that process may enable development of new antiviral and therapeutic strategies.
Ključne riječi (engleski)
Jezikengleski
Vrsta recenzijeNepoznato
URN:NBNurn:nbn:hr:184:007576
Datum izlaganja2021-07-06
SkupNaziv: The 45th FEBS Virtual Congress
Kratica: FEBS
Lokacija: Virtual meeting, Slovenija
Datum početka: 2021-07-03
Datum završetka: 2021-07-08
Vrsta izlaganja: Predavanje
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2023-04-05 07:47:38