prikaz prve stranice dokumenta Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile
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Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile
Frontiers in Immunology, 14 (2023); 1192057. https://doi.org/10.3389/fimmu.2023.1192057
Madela-Mönchinger, Julia Cecilia; Wolf, Silver Anthony; Wyler, Emanuel; Bauer, Agnieszka; Mischke, Marius; Möller, Lars; Juranić Lisnić, Vanda; Landthaler, Markus; Malyshkina, Anna; Voigt, Sebastian

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Madela Mönchinger, J. C., Wolf, S. A., Wyler, E., Bauer, A., Mischke, M., Möller, L. ... Voigt, S. (2023). Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile. Frontiers in Immunology, 14.. doi: 10.3389/fimmu.2023.1192057

Madela Mönchinger, Julia Cecilia, et al. "Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile." Frontiers in Immunology, vol. 14, 2023. https://doi.org/10.3389/fimmu.2023.1192057

Madela Mönchinger, Julia Cecilia, Silver Anthony Wolf, Emanuel Wyler, Agnieszka Bauer, Marius Mischke, Lars Möller, Vanda Juranić Lisnić, Markus Landthaler, Anna Malyshkina i Sebastian Voigt. "Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile." Frontiers in Immunology 14 (2023). https://doi.org/10.3389/fimmu.2023.1192057

Madela Mönchinger, J. C., et al. (2023) 'Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile', Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1192057

Madela Mönchinger JC, Wolf SA, Wyler E, Bauer A, Mischke M, Möller L, i sur.. Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile. Frontiers in Immunology [Internet]. 23.11.2023. [pristupljeno 23.12.2024.];14. doi: 10.3389/fimmu.2023.1192057

J. C. Madela Mönchinger, et al., "Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile", Frontiers in Immunology, vol. 14, Studeni 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:210736. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:210736
Podaci o radu
Naslov (engleski)Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile
AutorJulia Cecilia Madela-Mönchinger
AutorSilver Anthony Wolf
AutorEmanuel Wyler
AutorAgnieszka Bauer
AutorMarius Mischke
AutorLars Möller
AutorVanda Juranić Lisnić
AutorMarkus Landthaler
AutorAnna Malyshkina
AutorSebastian Voigt
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV). CMV is not only highly species-specific but also specialized in evading immune protection, and this specialization is in part due to characteristic genes encoded by a given virus. Here, we investigated whether rat CMV can infect XCR1+ DC and if infection of DC alters expression of cell surface markers and migration behavior. We demonstrate that wild-type RCMV and a mutant virus lacking the γ-chemokine ligand xcl1 (Δvxcl1 RCMV) infect splenic rat DC ex vivo and identify viral assembly compartments. Replication-competent RCMV reduced XCR1 and MHCII surface expression. Further, gene expression of infected DC was analyzed by bulk RNA-sequencing (RNA-Seq). RCMV infection reverted a state of DC activation that was induced by DC cultivation. On the functional level, we observed impaired chemotactic activity of infected XCR1+ DC compared to mock-treated cells. We therefore speculate that as a result of RCMV infection, DC exhibit diminished XCR1 expression and are thereby blocked from the lymphocyte crosstalk.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Immunology
Brojčani podacivol. 14, 1192057
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2023.1192057
URN:NBNurn:nbn:hr:184:210736
Datum objave publikacije2023-11-23
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fimmu.2023.1192057/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-12-21 07:57:13