In the course of brain development significant changes can be observed in the volumes of different brain parts and their ratios. The major changes are observed during the first few years of life. It is essential to be acquainted with the normal dynamic of cortical and subcortical grey matter development because it allows early detection of defective brain development thus providing an opportunity for earlier treatment. Therefore, it is vital to determine the normative values in order to detect certain impairment in the growth of the brain at an early stage and to provide proper treatment. In this study, we have analyzed the changes in the brain tissue volume in MR images that were obtained from 7 normal children in two different age groups: infants and two-year-old children. The results of this study showed a significant increase in the volume of cortical gray matter and thalamus in the first two years of life. Contrary to this finding, the basal ganglia did not show a statistically significant difference in volume in the analyzed age groups. The conclusion of this study is that the significant changes in the volume growth of cortical gray matter and thalamus occur postnatally, during the first few years of life, while the major changes in the volume growth of basal ganglia occur prenatally.