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The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study
Reviews in Cardiovascular Medicine, 22 (2021), 4; 1611-1620. https://doi.org/10.31083/j.rcm2204167
Sef, Davorin; Milošević, Milan; Oštrić, Marin; Meštrović, Tomislav; Jernej, Bojan; Kovačić, Slavica; Kovačević, Miljenko; Škrtić, Anita; Vidjak, Vinko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Sef, D., Milošević, M., Oštrić, M., Meštrović, T., Jernej, B., Kovačić, S. ... Vidjak, V. (2021). The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study. Reviews in Cardiovascular Medicine, 22. (4), 1611-1620. doi: 10.31083/j.rcm2204167

Sef, Davorin, et al. "The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study." Reviews in Cardiovascular Medicine, vol. 22, br. 4, 2021, str. 1611-1620. https://doi.org/10.31083/j.rcm2204167

Sef, Davorin, Milan Milošević, Marin Oštrić, Tomislav Meštrović, Bojan Jernej, Slavica Kovačić, Miljenko Kovačević, Anita Škrtić i Vinko Vidjak. "The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study." Reviews in Cardiovascular Medicine 22, br. 4 (2021): 1611-1620. https://doi.org/10.31083/j.rcm2204167

Sef, D., et al. (2021) 'The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study', Reviews in Cardiovascular Medicine, 22(4), str. 1611-1620. doi: 10.31083/j.rcm2204167

Sef D, Milošević M, Oštrić M, Meštrović T, Jernej B, Kovačić S, i sur.. The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study. Reviews in Cardiovascular Medicine [Internet]. 22.12.2021. [pristupljeno 09.11.2024.];22(4):1611-1620. doi: 10.31083/j.rcm2204167

D. Sef, et al., "The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study", Reviews in Cardiovascular Medicine, vol. 22, br. 4, str. 1611-1620, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:929089. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:929089
Podaci o radu
Naslov (engleski)The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid endarterectomy: a prospective pilot study
AutorDavorin Sef
AutorMilan Milošević
AutorMarin Oštrić
AutorTomislav Meštrović
AutorBojan Jernej
AutorSlavica Kovačić
AutorMiljenko Kovačević
AutorAnita Škrtić
AutorVinko Vidjak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA RADIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Radiologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Medicina rada i športa
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Components of carotid atherosclerotic plaque can be analysed preoperatively by non-invasive advanced imaging modalities such as magnetic resonance imaging (MRI). The expression of matrix metalloproteinase-9 protein (MMP-9), which has a potential role in remodelling of atherosclerotic plaques, can be analysed immunohistochemically. The aim of the present prospective pilot study is to analyse histological characteristics and expression of MMP-9 in carotid plaques of patients undergoing carotid endarterectomy (CEA) and to investigate the correlation with preoperative clinical symptoms and MRI features. Preoperative clinical assessment, MRI imaging, postoperative histological and immunohistochemical analyses were performed. Fifteen patients with symptomatic (7/15; 47%) and asymptomatic carotid artery stenosis undergoing CEA were included. Among symptomatic patients, 5 (71%) had recent stroke and 2 (29%) had recent transient ischaemic attack with a median timing of 6 weeks (IQR: 1, 18) before the surgery. Both groups did not significantly differ in respect to preoperative characteristics. Prevalence of unstable plaque was higher in symptomatic than asymptomatic patients, although it was not significant (63% vs. 37%, p = 0.077). The expression of MMP-9 in CD68 cells within the plaque by semiquantitative analysis was found to be significantly higher in symptomatic as compared to asymptomatic patients (86% vs. 25% with the highest expression, p = 0.014). The average microvascular density was found to be higher and lipid core area larger among both symptomatic patients and unstable carotid plaque specimens, although this did not reach statistical significance (p = 0.064 and p = 0.132, p = 0.360 and p = 0.569, respectively). Our results demonstrate that MRI is reliable in classifying carotid lesions and differentiating unstable from stable plaques. We have also shown that the expression of MMP-9 is significantly higher among symptomatic patients undergoing CEA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaReviews in Cardiovascular Medicine
Brojčani podacivol. 22, br. 4, str. 1611-1620
p-ISSN2153-8174
DOIhttps://doi.org/10.31083/j.rcm2204167
URN:NBNurn:nbn:hr:105:929089
Datum objave publikacije2021-12-22
URL dokumentahttps://imrpress.com/journal/RCM/22/4/10.31083/j.rcm2204167
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-01 10:05:31