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Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses
Journal of Clinical Medicine, 11 (2022), 5; 1284. https://doi.org/10.3390/jcm11051284
Bašković, Marko; Krsnik, Dajana; Himelreich Perić, Marta; Katušić Bojanac, Ana; Sinčić, Nino; Sonicki, Zdenko; Ježek, Davor

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Bašković, M., Krsnik, D., Himelreich Perić, M., Katušić Bojanac, A., Sinčić, N., Sonicki, Z. i Ježek, D. (2022). Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses. Journal of Clinical Medicine, 11. (5). doi: 10.3390/jcm11051284

Bašković, Marko, et al. "Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses." Journal of Clinical Medicine, vol. 11, br. 5, 2022. https://doi.org/10.3390/jcm11051284

Bašković, Marko, Dajana Krsnik, Marta Himelreich Perić, Ana Katušić Bojanac, Nino Sinčić, Zdenko Sonicki i Davor Ježek. "Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses." Journal of Clinical Medicine 11, br. 5 (2022). https://doi.org/10.3390/jcm11051284

Bašković, M., et al. (2022) 'Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses', Journal of Clinical Medicine, 11(5). doi: 10.3390/jcm11051284

Bašković M, Krsnik D, Himelreich Perić M, Katušić Bojanac A, Sinčić N, Sonicki Z, i sur.. Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses. Journal of Clinical Medicine [Internet]. 26.02.2022. [pristupljeno 22.11.2024.];11(5). doi: 10.3390/jcm11051284

M. Bašković, et al., "Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses", Journal of Clinical Medicine, vol. 11, br. 5, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:369326. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:369326
Podaci o radu
Naslov (engleski)Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury—Immunohistochemical and Biochemical Analyses
AutorMarko Bašković
AutorDajana Krsnik
AutorMarta Himelreich Perić
AutorAna Katušić Bojanac
AutorNino Sinčić
AutorZdenko Sonicki
AutorDavor Ježek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU STATISTIKU, EPIDEMIOLOGIJU I MEDICINSKU INFORMATIKU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Epidemiologija
Sažetak (engleski)
Testicular torsion potentially leads to acute scrotum and testicle loss, and requires prompt surgical intervention to restore testicular blood flow, despite the paradoxical negative effect of reperfusion. While no drug is yet approved for this condition, antioxidants are promising candidates. This study aimed to determine astaxanthin’s (ASX), a potent antioxidant, effect on rat testicular torsion−detorsion injury. Thirty-two prepubertal male Fischer rats were divided into four groups. Group 1 underwent sham surgery. In group 2, the right testis was twisted at 720° for 90 min. After 90 min of reperfusion, the testis was removed. ASX was administered intraperitoneally at the time of detorsion (group 3) and 45 min after detorsion (group 4). Quantification of caspase-3 positive cells and oxidative stress markers detection were determined immunohistochemically, while the malondialdehyde (MDA) value, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were determined by colorimetric assays. The number of apoptotic caspase-3 positive cells and the MDA value were lower in group 4 compared to group 2. A significant increase in the SOD and GPx activity was observed in group 4 compared to groups 2 and 3. We conclude that ASX has a favorable effect on testicular ischemia-reperfusion injury in rats.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 11, br. 5, 1284
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm11051284
URN:NBNurn:nbn:hr:105:369326
Datum objave publikacije2022-02-26
ProjektŠifra: KK.01.1.1.01.0008
Naziv (hrvatski): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Voditelj: Slobodan Vukičević
Pravna nadležnost: eu
Financijer: EK
URL dokumentahttps://www.mdpi.com/2077-0383/11/5/1284
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-06 08:26:21