prikaz prve stranice dokumenta Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?
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Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?
European Journal of Clinical Microbiology & Infectious Diseases, 33 (2014), 12; 2231-2236. https://doi.org/10.1007/s10096-014-2187-7
Đaković Rode, Oktavija; Jemeršić, Lorena; Brnić, Dragan; Pandak, Nenad; Mikulić, Radojka; Begovac, Josip; Vince, Adriana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Đaković Rode, O., Jemeršić, L., Brnić, D., Pandak, N., Mikulić, R., Begovac, J. i Vince, A. (2014). Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?. European Journal of Clinical Microbiology & Infectious Diseases, 33. (12), 2231-2236. doi: 10.1007/s10096-014-2187-7

Đaković Rode, Oktavija, et al. "Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?." European Journal of Clinical Microbiology & Infectious Diseases, vol. 33, br. 12, 2014, str. 2231-2236. https://doi.org/10.1007/s10096-014-2187-7

Đaković Rode, Oktavija, Lorena Jemeršić, Dragan Brnić, Nenad Pandak, Radojka Mikulić, Josip Begovac i Adriana Vince. "Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?." European Journal of Clinical Microbiology & Infectious Diseases 33, br. 12 (2014): 2231-2236. https://doi.org/10.1007/s10096-014-2187-7

Đaković Rode, O., et al. (2014) 'Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?', European Journal of Clinical Microbiology & Infectious Diseases, 33(12), str. 2231-2236. doi: 10.1007/s10096-014-2187-7

Đaković Rode O, Jemeršić L, Brnić D, Pandak N, Mikulić R, Begovac J, i sur.. Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?. European Journal of Clinical Microbiology & Infectious Diseases [Internet]. 12.2014. [pristupljeno 22.11.2024.];33(12):2231-2236. doi: 10.1007/s10096-014-2187-7

O. Đaković Rode, et al., "Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?", European Journal of Clinical Microbiology & Infectious Diseases, vol. 33, br. 12, str. 2231-2236, Prosinac 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:284149. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:284149
Podaci o radu
Naslov (engleski)Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?
AutorOktavija Đaković Rode
AutorLorena Jemeršić
AutorDragan Brnić
AutorNenad Pandak
AutorRadojka Mikulić
AutorJosip Begovac
AutorAdriana Vince
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We assessed hepatitis E virus (HEV) seroprevalence in patients with hepatic disorders as well as in human immunodeficiency virus (HIV)-infected patients and emphasised the issue of possible non-specific anti-HEV seroresponse and need for combining diagnostic methods for hepatitis E diagnosis. Over a two-year period, from March 2011 to February 2013, we determined anti-HEV immunoglobulin M (IgM) and IgG by enzyme immunoassays (EIA; Mikrogen, Germany) in 504 hepatitis patients negative for acute viral hepatitis A-C. Furthermore, 88 samples from randomly selected consecutive HIV-infected patients were also analysed. All EIA reactive samples were additionally tested by line immunoblot assays (LIA; Mikrogen, Germany). HEV nested reverse transcription polymerase chain reaction (RT-PCR) was carried out in 14 anti-HEV IgM LIA-positive patients. Anti-HEV IgM or IgG were detected in 16.9 % of patients by EIA and confirmed by LIA in 10.7 % [95 % confidence interval (CI) 8.3-13.7 %] of hepatitis patients. HEV RNA was detected in five patients. The agreement between EIA and LIA assessed by Cohen's kappa was 0.47 (95 % CI 0.55-0.75) for IgM and 0.83 (95 % CI 0.78-0.93) for IgG. Anti-HEV IgM and IgG seroprevalence in HIV-infected patients was 1.1 %, respectively. Our findings show a rather high HEV seroprevalence in patients with elevated liver enzymes in comparison to HIV-infected patients. Discordant findings by different methods stress the need to combine complementary methods and use a two-tier approach with prudent interpretation of reactive serological results for hepatitis E diagnosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEuropean Journal of Clinical Microbiology & Infectious Diseases
Brojčani podacivol. 33, br. 12, str. 2231-2236
p-ISSN0934-9723
DOIhttps://doi.org/10.1007/s10096-014-2187-7
URN:NBNurn:nbn:hr:105:284149
Datum objave publikacije2014-12
URL dokumentahttps://doi.org/10.1007/s10096-014-2187-7
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:09:30