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Targeting tumor markers with antisense peptides: an example of human prostate specific antigen
International Journal of Molecular Sciences, 20 (2019), 9; https://doi.org/10.3390/ijms20092090
Štambuk, Nikola; Konjevoda, Paško; Turčić, Petra; Šošić, Hrvoje; Aralica, Gorana; Babić, Damir; Seiwerth, Sven; Kaštelan, Željko; Kujundžić, Renata Novak; Wardega, Piotr; Žutelija, Jelena Barać; Gračanin, Ana Gudelj; Gabričević, Mario

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Štambuk, N., Konjevoda, P., Turčić, P., Šošić, H., Aralica, G., Babić, D. ... Gabričević, M. (2019). Targeting tumor markers with antisense peptides: an example of human prostate specific antigen. International Journal of Molecular Sciences, 20. (9). doi: 10.3390/ijms20092090

Štambuk, Nikola, et al. "Targeting tumor markers with antisense peptides: an example of human prostate specific antigen." International Journal of Molecular Sciences, vol. 20, br. 9, 2019. https://doi.org/10.3390/ijms20092090

Štambuk, Nikola, Paško Konjevoda, Petra Turčić, Hrvoje Šošić, Gorana Aralica, Damir Babić, Sven Seiwerth, et al. "Targeting tumor markers with antisense peptides: an example of human prostate specific antigen." International Journal of Molecular Sciences 20, br. 9 (2019). https://doi.org/10.3390/ijms20092090

Štambuk, N., et al. (2019) 'Targeting tumor markers with antisense peptides: an example of human prostate specific antigen', International Journal of Molecular Sciences, 20(9). doi: 10.3390/ijms20092090

Štambuk N, Konjevoda P, Turčić P, Šošić H, Aralica G, Babić D, i sur.. Targeting tumor markers with antisense peptides: an example of human prostate specific antigen. International Journal of Molecular Sciences [Internet]. 28.04.2019. [pristupljeno 30.04.2024.];20(9). doi: 10.3390/ijms20092090

N. Štambuk, et al., "Targeting tumor markers with antisense peptides: an example of human prostate specific antigen", International Journal of Molecular Sciences, vol. 20, br. 9, Travanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:903196. [Citirano: 30.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:903196
Podaci o radu
Naslov (engleski)Targeting tumor markers with antisense peptides: an example of human prostate specific antigen
AutorNikola Štambuk
AutorPaško Konjevoda
AutorPetra Turčić
AutorHrvoje Šošić
AutorGorana Aralica
AutorDamir Babić
AutorSven Seiwerth
AutorŽeljko Kaštelan
AutorRenata Novak Kujundžić
AutorPiotr Wardega
AutorJelena Barać Žutelija
AutorAna Gudelj Gračanin
AutorMario Gabričević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The purpose of this paper was to outline the development of short peptide targeting of the human prostate specific antigen (hPSA), and to evaluate its effectiveness in staining PSA in human prostate cancer tissue. The targeting of the hPSA antigen by means of antisense peptide AVRDKVG was designed according to a three-step method involving: 1. The selection of the molecular target (hPSA epitope), 2. the modeling of an antisense peptide (paratope) based on the epitope sequence, and 3. the spectroscopic evaluation of sense-antisense peptide binding. We then modified standard hPSA immunohistochemical staining practice by using a biotinylated antisense peptide instead of the standard monoclonal antibody and compared the results of both procedures. Immunochemical testing on human tissue showed the applicability of the antisense peptide technology to human molecular targets. This methodology represents a new approach to deriving peptide ligands and potential lead compounds for the development of novel diagnostic substances, biopharmaceuticals and vaccines.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 20, br. 9
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20092090
URN:NBNurn:nbn:hr:105:903196
Datum objave publikacije2019-04-28
URL dokumentahttp://doi.org/10.3390/ijms20092090
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:35:44