Tuberculosis and Covid-19 are caused by very different organisms but have similar symptoms and necessary preventive measures. Tuberculosis is caused by bacteria, and it is a chronic infection with delayed symptoms manifestations. Covid-19 is caused by a virus, and the disease is acute with rapid onset of symptoms. Both diseases are respiratory, acquired by aerosol inhalation, and preventive measures in both diseases are the same. Covid-19 pandemic has caused major changes in functioning of the health care system and disease management, especially tuberculosis. Changes are due to health care system focusing on subduing the Covid19 pandemic, implementation of epidemiologic countermeasures and economic difficulties. Hospitals were closed and space and personnel allocated to management of Covid-19 patients. Pulmonology hospitals wards and personnel, who were treating tuberculosis, were especially involved in these changes. Patients had difficulty acquiring health care services, diagnostic procedures were postponed or not performed at all, therapy was not supervised and patient follow-up was lacking. Tuberculosis contact tracing was also negatively affected. Furthermore, Covid-19 pandemic caused severe economic deterioration, poverty and nutritional deficiency which all enhance tuberculosis incidence. Home isolations prevented tuberculosis spreading in the population but facilitated tuberculosis spreading among household contacts. The effect was poor health care of tuberculosis patients with lacking diagnostic therapy and screening procedures and deteriorating social issues which promoted tuberculosis spreading in the general population. Therefore, number of reported tuberculosis patients has fallen and the number of tuberculosis deaths has risen. Covid-19 pandemic has deteriorated tuberculosis epidemiologic situation in the World, and further determined efforts are necessary to lower tuberculosis incidence and mortality.