The objective of this study was to determine the relation between homocysteine (Hcy), folate, vitamin B12 and bone mineral density (BMD) in correlation with age, nutrition and lifestyle. Inversely proportional predictors of Hcy level are levels of serum folate (S), erythrocyte folate (E) and vitamin B12 for the entire sample, folate (E) and vitamin B12 in omnivores, folate (E) in vegetarians and vitamin B12 in omnivorous postmenopausal women. Most significant BMD predictor for the entire sample and for all measurement points is carbohydrate intake (% kJ/day), BMD predictor for femoral neck and total hip is pasta, rise, bread and potato intake (g/day) as well as sodium intake. Hcy level is a BMD predictor for the total hip. In omnivores, most significant BMD predictor for lumbar spine is vitamin B12 intake, for femoral neck BMD fiber and triglyceride intake and level of phosphorous, for total hip BMD carbohydrate intake as well as vitamin A and triglycerides. Most significant BMD predictor for vegetarians in all measurement points is vitamin A intake, for femoral neck BMD and femur BMD is also triglyceride intake. Carbohydrate intake is only the predictor for total hip BMD. In omnivorous postmenopausal women the most significant BMD predictor in all measurement points is carbohydrate intake, (% kJ/day), BMD predictor for femoral neck and total hip is also vitamin K intake. Intake of zinc is the BMD predictor for the total hip. Mentioned relations indicate low biological value in correlation with age, gender and menopausal status. Distinction between BMD has been determined in all measurement points within all groups. Lumbar spine BMD and femoral neck BMD showed the highest values. Nutrition differed between the groups.