The liver is a key organ in biotransformation and removal of harmful substances from the body. Liver damage is most often caused by excessive consumption of drugs, alcohol, fatty and fried foods, oxidative stress and free radicals. Numerous studies have shown the hepatoprotective effect of phytochemicals both in the prevention and treatment of some forms of liver disease. Their positive effect is attributed primarily to antioxidant activity. Antioxidants are a group of different compounds that provide protection against the harmful effects of free radicals. Today, various plants and herbal preparations are increasingly used in the prevention and protection against liver disease. Polyphenols are the most well-known micronutrients abundant in the diet. The health effects of polyphenols depend on the amount consumed and their bioavailability. The mechanisms that provide a hepatoprotective effect are many, and include antioxidant activity, improving detoxification and protection against glutathione loss, as well as inhibition of leukotriene synthesis. The aim of this study was to investigate the hepatoprotective effect of phytochemicals present in many plant foods.