Codling moth Cydia pomonella L. is one of the most important apple pests whose population is growing from year to year. The aim of this study was to determine the effectiveness of four treatments (1.- based on baculovirus CpGV 2.- based on deltamethrin,beta cyfluthrin and alpha-cipemetrina (from the group of synthetic pyrethroids), 3.- on the basis of kaolin, 4.- control treatment), applied on the basis of two different methods of time control (A- based on the catch on the pheromones; B on the basis of biology and methods Wildbolz, 1965), on the three apple varieties (Melrose, Jonagored, and Golden Delicious clone B). The experiment was performed at the Agricultural Institute Osijek. The results of the efficiacy according to Abbott (1925) are as follows; the efficacy of treatments 1. (baculovirus) ranged from 78% to 95%, the efficiacy of treatment 2. refering to the affect of three preparations from the group of synthetic pyrethroids ranged from 96% - 97%, the efficiacy of treatment 3. in which we used ground kaolin clay, ranged between 21.5 to 57%. Analysis of variance showed that the yield and damage on apples significantly differed between treatments in all three years of research. In this research, it was realized a highly significant negative correlation between yield and damage apples (r = -0756). Influence of the different methods of determining control did not show statistically significant differences either in the domain of yield or damage except in one year testing when the level of significanse was 0,5. The results of time control showed that using pheromone traps achieved equally good results as establishing the biology of codling moth in insect cage combined with monitoring developmental stages of pests using methods Wildbolz, 1962, so the assumption that the time of control on the basis of biology is more accurate and produces better results, can not be accepted. Combined analysis of variance showed the existence of highly significant differences between years, considering crop damage and the yield. Less significance occurred to source of variation treatment - time of control - variety. According to market prices (TC) treatment 1 and treatment 2 had ecomical coefficient above 1 with tendency of significant growth, while treatment 3 was on the very boder of profitability and treatment 4 was uneconomical. On the basis of carried out research the control of codling moth in Eastern Croatia we conclude that the decision for controling could be made on the basis of pheromones monitoring and summarizing effective temperatures as codling mothʹs life stages depend on climate conditions and vary from year to year. It is very important to make the best choice of preparations and at the same time be sure of their positive effect on the environment and human health.