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Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly
Nature Communications, 13 (2022), 1; 7307. https://doi.org/10.1038/s41467-022-34957-4
Matković, Jurica; Ghosh, Subhadip; Ćosić, Mateja; Eibes, Susana; Barišić, Marin; Pavin, Nenad; Tolić, Iva M.

Institucijski repozitorij: Repozitorij Prirodoslovno-matematičkog fakulteta

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Matković, J., Ghosh, S., Ćosić, M., Eibes, S., Barišić, M., Pavin, N. i Tolić, I. M. (2022). Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly. Nature Communications, 13. (1). doi: 10.1038/s41467-022-34957-4

Matković, Jurica, et al. "Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly." Nature Communications, vol. 13, br. 1, 2022. https://doi.org/10.1038/s41467-022-34957-4

Matković, Jurica, Subhadip Ghosh, Mateja Ćosić, Susana Eibes, Marin Barišić, Nenad Pavin i Iva M. Tolić. "Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly." Nature Communications 13, br. 1 (2022). https://doi.org/10.1038/s41467-022-34957-4

Matković, J., et al. (2022) 'Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly', Nature Communications, 13(1). doi: 10.1038/s41467-022-34957-4

Matković J, Ghosh S, Ćosić M, Eibes S, Barišić M, Pavin N, i sur.. Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly. Nature Communications [Internet]. 27.11.2022. [pristupljeno 24.11.2024.];13(1). doi: 10.1038/s41467-022-34957-4

J. Matković, et al., "Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly", Nature Communications, vol. 13, br. 1, Studeni 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:679274. [Citirano: 24.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:217:679274
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Naslov (engleski)Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly
AutorJurica Matković
AutorSubhadip Ghosh
AutorMateja Ćosić
AutorSusana Eibes
AutorMarin Barišić
AutorNenad Pavin
AutorIva M. Tolić
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Sažetak (engleski)
Mitotic spindle assembly is crucial for chromosome segregation and relies on bundles of microtubules that extend from the poles and overlap in the middle. However, how these structures form remains poorly understood. Here we show that overlap bundles arise through a network-to-bundles transition driven by kinetochores and chromosomes. STED super-resolution microscopy reveals that PRC1-crosslinked microtubules initially form loose arrays, which become rearranged into bundles. Kinetochores promote microtubule bundling by lateral binding via CENP-E/kinesin-7 in an Aurora B-regulated manner. Steric interactions between the bundle-associated chromosomes at the spindle midplane drive bundle separation and spindle widening. In agreement with experiments, theoretical modeling suggests that bundles arise through competing attractive and repulsive mechanisms. Finally, perturbation of overlap bundles leads to inefficient correction of erroneous kinetochore-microtubule attachments. Thus, kinetochores and chromosomes drive coarsening of a uniform microtubule array into overlap bundles, which promote not only spindle formation but also chromosome segregation fidelity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 13, br. 1, 7307
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-022-34957-4
URN:NBNurn:nbn:hr:217:679274
Datum objave publikacije2022-11-27
ProjektŠifra: PZS-2019-02-7653
Naziv (hrvatski): Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena
Naziv (engleski): Mechanisms of microtubule bundle formation required for spindle maturation
Kratica: SpindleForm
Voditelj: Iva Marija Tolić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Programme Research Cooperability
ProjektŠifra: 855158
Naziv (hrvatski): Molekularno podrijetlo aneuploidija u zdravim i bolesnim ljudskim tkivima
Naziv (engleski): Molecular origins of aneuploidies in healthy and diseased human tissues
Kratica: ANEUPLOIDY
Voditelj: Iva Marija Tolić
Pravna nadležnost: eu
Financijer: Europska komisija
ProjektŠifra: KK.01.1.1.04.0057
Naziv (hrvatski): Inovativni protokoli mikroskopije za interdisciplinarna istraživanja u biomedicini
Naziv (engleski): Inovative microscopy protocols for interdisciplinary research in biomedicine
Kratica: IPSted
Voditelj: Iva Marija Tolić
Pravna nadležnost: eu
Financijer: Europska komisija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://www.nature.com/articles/s41467-022-34957-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomena© The Author(s) 2022. s This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received: 28 March 2022; Accepted: 11 November 2022; Published: 27 November 2022.
Datum i vrijeme pohrane2024-08-31 20:53:40