prikaz prve stranice dokumenta Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
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Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
Nature Communications, 7 (2016); 10298. https://doi.org/10.1038/ncomms10298
Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukušić, Bruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glunčić, Matko; Pavin, Nenad; Tolić, Iva Marija Više autora...

Institucijski repozitorij: Repozitorij Prirodoslovno-matematičkog fakulteta

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Kajtez, J., Solomatina, A., Novak, M., Polak, B., Vukušić, B., Rüdiger, J. ... Tolić, I. M. (2016). Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores. Nature Communications, 7.. doi: 10.1038/ncomms10298

Kajtez, Janko, et al. "Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores." Nature Communications, vol. 7, 2016. https://doi.org/10.1038/ncomms10298

Kajtez, Janko, Anastasia Solomatina, Maja Novak, Bruno Polak, Bruno Vukušić, Jonas Rüdiger, Gheorghe Cojoc, et al. "Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores." Nature Communications 7 (2016). https://doi.org/10.1038/ncomms10298

Kajtez, J., et al. (2016) 'Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores', Nature Communications, 7. doi: 10.1038/ncomms10298

Kajtez J, Solomatina A, Novak M, Polak B, Vukušić B, Rüdiger J, i sur.. Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores. Nature Communications [Internet]. 2016. [pristupljeno 23.11.2024.];7. doi: 10.1038/ncomms10298

J. Kajtez, et al., "Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores", Nature Communications, vol. 7, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:208275. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:217:208275
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Naslov (engleski)Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
AutorJanko Kajtez
AutorAnastasia Solomatina
AutorMaja Novak
MBZ: 344456
AutorBruno Polak
AutorBruno Vukušić
AutorJonas Rüdiger
AutorGheorghe Cojoc
AutorAna Milas
AutorIvana Šumanovac Šestak
AutorPatrik Risteski
AutorFederica Tavano
AutorAnna H. Klemm
AutorEmanuele Roscioli
AutorJulie Welburn
AutorDaniela Cimini
AutorMatko Glunčić
AutorNenad Pavin
AutorIva Marija Tolić
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Sažetak (engleski)
During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between sister kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in HeLa and PtK1 cells that a bundle of non-kinetochore microtubules, which we term ‘bridging fibre’, bridges sister k-fibres and balances the interkinetochore tension. We found PRC1 and EB3 in the bridging fibre, suggesting that it consists of antiparallel dynamic microtubules. By using a theoretical model that includes a bridging fibre, we show that the forces at the pole and at the kinetochore depend on the bridging fibre thickness. Moreover, our theory and experiments show larger relaxation of the interkinetochore distance for cuts closer to kinetochores. We conclude that the bridging fibre, by linking sister k-fibres, withstands the tension between sister kinetochores and enables the spindle to obtain a curved shape.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 7, 10298
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/ncomms10298
URN:NBNurn:nbn:hr:217:208275
Datum objave publikacije2016
URL dokumentahttps://www.nature.com/articles/ncomms10298
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomenaThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
Datum i vrijeme pohrane2020-02-09 14:31:04