Non-invasive treatment of caries is a contemporary approach to the treatment of the most widespread infectious disease. The therapy is based on caries prevention, timely detection of lesions, remineralization and minimal removal of infected tooth structure. In the diagnosis of the lesion with the tactile method and X-rays we introduced the use of modern devices such as DIAGNOdent, which allows early detection of caries. The laser is used in prevention and diagnosis, suppression of microorganisms, preparation of dentin and enamel and removal of caries affected tissue. Ozone therapy is helpful for remineralization of tooth structure. Ozone reduces the number of microorganisms in carious lesions, reducing inhibitors of remineralization and allows the dentinal tubules to open, which aids the process of remineralization. Today we use some of the non-invasive methods for the targeted removal of the infected tooth tissue while saving the healthy tissue, such as: ART technique, which is based on the use of hand-held instruments, "step-wise" technique, in which we try to preserve the vitality of dental pulp, chemomechanical methods, where a special gel is used to color the carious tissue, photoactive disinfection, which is based on the binding of photosensitive molecules in the membrane of bacteria and finally, minimally invasive preparation, which uses a special drill with small head.