Objectives: The aim of this study was to assess periodontal conditions in patients with early stage CLL and to compare it with the periodontal status of age-matched healthy controls and also to analyze the relationship between periodontal and hematological parameters in CLL patients. Materials and Methods: The study was conducted on 60 subjects divided into two groups. The test group included 30 patients with CLL (stage Rai 0), while the control group included 30 systemically healthy age-matched subjects. Exclusion criteria for both groups were: presence of other systemic disease, history of treatment for periodontitis, use of antibiotics during the previous 3 months, use of medications which are known to be risk factors for periodontitis. The participants with at least eight teeth (24 participants from the test group, 28 participants from the control group) underwent a full mouth examination and periodontal condition was assessed using periodontal indices (API, PBI, PPD, REC, CAL). Medical data for CLL patients were collected from the patients’ records, while hematological data were obtained from the haemogram performed on the same day as the clinical examination. Results: Difference between groups was statistically significant for age, number of teeth and frequency of dental checkups (p<0.05). Patients with CLL had significant ly higher average values of periodontal indices (API 0.81±0.18; PBI 2.72±0.68; PPD 3.40±0.53; REC 1.95±0.87; CAL 4.37±0.80) compared to the control group (API 0.69±0.15; PBI 1.91±0.45; PPD 2.51±0.40; REC 0.99±0.54; CAL 3.00±0.58). The correlation coefficients between age and periodontal indices showed statistically significance between age and REC (r=0.357; p<0.01), and age and CAL (r=0.295; p<0.05). Age was not statistically significant covariate for CAL (F=2.205; p>0.05), only for REC (F=4.601; p<0.05). After the removal of the statistical effect of age, the difference in REC between CLL and control group remained statistically significant (F=19.732; p<0.01; eta2=0.287). Statistically significant association between periodontal and hematological parameters in CLL patients was not found (p>0.05). Conclusions: The results of this study showed that participants with CLL had worse periodontal status compared to the healthy subjects from the control group, but the relationship between periodontal and hematological parameters was not proved.