Considering the present of the pollution in the marine environment, regional sea programs have been developed, to monitor the concentration of chemical contaminants and biological measurements of the effect of the contaminants on marine organisms in each of the assessment regions. Member States of the MSFD (Marine Strategy Framework Directive), within the framework of their regional seas, are required by MSFD to select the relevant contaminants. Pollutant monitoring and assessment programs, between Member States, should be harmonized in order to maintain equality and allow the comparisons between regions in order to protect the marine environment. Monitoring contaminants of priority chemical and biological measurements may vary between regions due to different environmental conditions and other regional problems. Monitoring programs include pollution concentrations in ecological matrices such as: water, sediment and biota, and quantification of biological effects of pollution at different levels of biological organization (organism, population, community, ecosystem). Marine Strategy Framework Directive - Directive 2008/56 / EZ is the legal framework for Community strategic action in the field of the marine environment. The MDSF applies to the Communities or to the Member States which take the necessary measures to maintain good environmental status (GES). MSFD is organized by descriptors. Descriptor 8 describes the concentrations of the contaminants and interprets the monitoring data according to the objective of protection against marine pollution. Within regional conventions, Member States use a range of chemical analytical methods and biological performance methods. In order to interpret the monitoring and evaluation data in a correct way, various norms / criteria and evaluation thresholds have been developed. These include background concentrations within OSPAR (Northeast Atlantic Convention), EQS (Environmental Quality Standards) developed through the WFD (Water Framework Directive 2000/60 / EC), processes and criteria for environmental impact assessment (EACs) developed through OSPAR processes. The aim is to establish common rules for the quality of the marine environment, and to carry out the analyzes and the measurements in order to preserve the health of organisms, populations, communities and ecosystems. OSPAR, HELCOM (Helsinki Commission, Baltic Commission for the Protection of the Marine Environment) and MEDPOL (Program for the Assessment and Control of Marine Pollution in the Mediterranean Region) are regional conventions that have developed strong statistical approaches, to analyze chemical monitoring data, and monitor biological effects. Integration is facilitated by consistent sets of environmental level goals. Further development of EU and regional conventions is needed to expand the area of target levels to include more pollutants and biological effects. International experience and integration between regional conventions and the EU significantly facilitates the implementation of the MSFD strategy. The Republic of Croatia is implementing a system of monitoring programs for the continous assessment of the state of the Adriatic Sea, which was developed as the first action program of the marine and coastal zone management strategy, under the Directive 2008/56 / EZ.