The skin is the largest organ of vertebrates and is crucial for defense as well as survival. Any injury causes loss of skin integrity resulting in functional imbalance which can be accompanied by disability or even death. Wound healing is an attempt by injured tissue to restore normal function and structural integrity after injury. Skin repair in adults is usually achieved by fibrosis resulting in scarring. In mammals, the skin of the fetus regenerates flawlessly unlike adult skin. A wound is defined as damage or interruption of normal anatomical structure and function. Wounds were divided into acute, chronic and complicated, and by type of mechanical force or tool that caused damage to: stab wounds, cut wounds (cuts), cuts, lacerations, torn and bruised wounds, bruised wounds, crushed wounds, bite wounds, shot wounds and explosive wounds. Considering the present contamination of wounds, we have further divided them into: clean surgical wounds, clean contaminated wounds, contaminated wounds and unclean wounds. Multiple healing stages occur at the same time within a single wound. The healing process is divided into three phases: inflammatory, proliferation and maturation. Inflammation begins immediately after removal of wound contaminants and damaged or dead tissue. The proliferative phase represents the repair phase of the injured tissue during which the blood flow, components of the extracellular matrix and epithelial wound cover are restored. In the process of maturation or remodeling, the collagen is reorganized and the tissue strength returns like as it was before wounding. Regenerative medicine is defined as a new and rapidly growing field of biomedicine whose research focuses on the replacement and restoration of damaged cells, tissues and organs. This can be achieved through a process of dedifferentiation, transdifferentiation and reprogramming. Regenerative therapies consist of various technological approaches such as soluble molecules, gene targeting, stem cell treatment, tissue engineering and cell reprogramming. Therapy is performed on a growth factor or cellular basis.