This paper discusses the concepts related to health problems that appear when working on computer. The paper first defines the basic concept of those health problems and then elaborates these problems and discusses their causes, types, prevention, and also the legal framework. After the introduction, the paper discuss the health problems in working with computer or, in other words, the causes of the same, but also psyscofisiological disturbances, optical disturbances, and statodynamic disturbances. After that, the same chapter discuss also the prevention of the problems that concerns working with computer, and also is emphasized the problem of computer addiction, primarily Internet and computer games. This chapter also discusses the legal frame of safety in working with computer. In this paper also, based on the research of available literature, is formed hypothetical model of protection on work with computer in travel agency to justify the strategy for health protection in doing that kind of work. So, the third chapter first discusses the safety conditions in working with computer in that agency, and after that the attention is paid to the different aspects of safety like the safety of monitor, the safety of keyboard, the safety of working environment, and the safety of the other aspects. This chapter also pays attention on program equipment that this agency uses to ensure its employees in working with computer. This especially means the reservation system that is actually one of the principal aspects of this company's business and one of the bases of it's business. Further is also described the software used in antivirus protection what is also very important in the company's business. At the end of the paper there are the most important conclusions that actually respond to the research question given in the introduction